HHCPM: What do we know about this cannabinoid so far?

• What is HHCPM and how is it produced?
• Structure
• Effects
• User experiences
• Side effects
• Conclusion
• FAQ

What is HHCPM and how is it produced?

HHCPM is a (semi)synthetic cannabinoid derived from HHCP (hexahydrocannabiphorol). The full name is hexahydrocannabiphorol monomethylether – i.e. hexahydrocannabiphorol (HHCP), to which monomethylether, a specific type of ether group, has been added.

HHCPM does not occur in cannabis; it is a laboratory-prepared compound, produced synthetically from precursors, typically HHCP or a similar compound. It is created through complex chemical processes, including synthesis, molecular modification, purification, and thorough testing 🔬.

Key steps in the production of HHCPM include 👇:

• Hydrogenation: adding hydrogen to the cannabinoid structure – this creates a hexahydro form for greater stability and better fat solubility
• Attaching an ethyl group (CH2CH3) to a specific part of the molecule
• Methylation: the final step is the O-methylation of phenolic –OH on the aromatic ring of HHCP, creating methyl ether (–O–CH3)

After these reactions, the raw product is purified (e.g., by chromatography) to a high degree of purity. The resulting substance is low viscosity (liquid), which facilitates its use and storage at room temperature.

Structure

The molecular formula of HHCPM is C24H38O2 (24 carbon atoms, 38 hydrogen atoms, and 2 oxygen atoms).

Structurally, HHCPM is a dibenzopyran molecule (like THC) with a heptyl side chain (7 carbons) on the aromatic core and a methyl ether group (–O–CH3) instead of a free hydroxyl group.

In other words, HHCPM is an O-methylated derivative of HHCP, which means that the phenolic hydroxyl group (–OH) of the cannabinoid HHCP has been replaced by a methoxy group. This modification increases the lipophilicity of the molecule and may affect its binding to receptors in the endocannabinoid system (ECS).

HHCPM is a hydrogenated compound (similar to HHC or H4CBD) and consists of two stereoisomers: 9(R)-HHCP methyl ether and 9(S)-HHCP methyl ether.

 

Recent scientific findings suggest that the 9(R) isomer effectively binds to CB1 receptors in the ECS and causes psychoactive effects. In contrast, the 9(S) isomer is considered inactive, as demonstrated by a 2023 study focusing on HHC, according to which 9(R) exhibits similar activity to THC on CB1 and CB2 receptors.

Effects

HHCPM belongs to the group of psychoactive cannabinoids, i.e., substances that act as agonists ("triggers") of CB1 receptors (found primarily in the central nervous system, in the brain) and CB2 receptors (in the immune system).

There are currently no scientific studies available on the effects of HHCPM. But for now, we know that it has psychoactive effects and that the ratio of 9(R) and 9(S) isomers in the product will influence the effects.

HHCPM may 👇:

• induce feelings of euphoria and relaxation
• affect perception
• increase appetite

User experiences

On the e-shop cannabinoidswithturkey.com, a user described HHCPM as one of the strongest cannabinoids, causing a feeling of "scatterbrainedness." The effects are said to kick in faster than with HHCP, but the peak is not as long, while the comedown lasts longer.

Various experiences have been reported on the Reddit discussion forum:

• One user described preroll as strong, with longer-lasting effects, although without a significant peak. The following day, they experienced slight brain fog.
• Another user described a 30% HHCPM cartridge as weaker, comparing the effects to H4CBD.

 

Side effects

Commonly recognized side effects of psychoactive cannabinoids may occur, especially at higher doses, including red eyes, dry mouth, rapid heartbeat, and difficulty falling asleep.

In case of overdose, unpleasant psychological symptoms may occur, including anxiety, paranoia, dizziness, and disorientation.

The intensity of these effects will depend not only on the user's age, body proportions, health, metabolism, and sensitivity, but also on the size of the dose and method of consumption.

Conclusion

HHCPM is a derivative of HHCP and is produced exclusively in laboratories. Thanks to its specific structure, it offers a different experience. According to some users, the effects kick in faster than with HHCP, but they don't last as long, and the comedown is more gradual.

Although HHCPM has not yet been researched, it seems to be pushing the world of cannabis compounds a little further 💥.

 

 

Sources:

• caymanchem.com/product/40488/9(s)-hexahydrocannabiphorol-methyl-ether
• cannabissciencetech.com/view/cannabinoid-ethers-identification-binding-interactions-and-their-adme-properties
• pubs.acs.org/doi/10.1021/acschembio.3c00254
• pubmed.ncbi.nlm.nih.gov/7420350/
• workpage.ews-nfp.bg/wp-content/uploads/2024/12/EU-EWS-RCS-FN-2024-0045_10-hydroxyhexahydrocannabinol-10-OH-HHC.pdf

 

Author: Patricie Mikolášová

 

   

Photo: AI

"All information provided on this website, as well as the information provided through this website, is for educational purposes only. None of the information contained herein is intended as a substitute for medical diagnosis and such information is not to be considered medical advice or recommended treatment. This website does not promote, endorse or advocate the legal or illegal use of narcotic drugs or psychotropic substances or the commission of any other illegal activity. Please see our Disclaimer for further information."