HHCH: On the origins, effects and pitfalls of a new cannabinoid on the market
- What is HHCH and what is its origin?
- What are the effects of HHCH?
- Side effects and other pitfalls
- Safety first
- In conclusion: HHCH products and legal status
What is HHCH and what is its origin?
The compound HHCH was first synthesized in 1942 by the American chemist Roger Adams. In his scientific study, he stated that HHCH is more potent than the pentyl and heptyl homologue or the unsaturated analogue of THC (tetrahydrocannabinol).
HHCH (hexahydrocannabihexol) is a semi-synthetic cannabinoid derivative that is produced exclusively in the laboratory. It is produced by hydrogenating a distillate of THCH (tetrahydrocannabinol) and converting it to HHCH. It takes the form of a thick, high-viscosity oil.
The molecular formula is C22H34O2. And because this compound is formed by hydrogenation, it consists of two different stereoisomers, namely the isomers 9(R)-HHCH and 9(S)-HHCH, similar to the cannabinoids H4CBD and HHC.
What are the effects of HHCH?
It is now generally known that said 9(R) and 9(S) molecules, specifically their ratio in hydrogenated compounds, affect the efficacy and strength of the product. If the 9(R) isomer predominates in the product, the product will be more effective, typically a 1:1 ratio of molecules is used.
A 2023 study looking at HHC confirmed that the 9(R) molecule has a high affinity for CB1 receptors in the endocannabinoid system, causing it to have a psychoactive effect, while 9(S) earns the designation of inactive ingredient.
With regard to the effects of HHC, it is generally reported that the psychoactive effects are similar to those of THC, with slightly milder effects compared to HHCP and these effects lasting longer than those of HHC. HHCH can last for 2-8 hours.
Since Roger Adams indicated in his study that it is a potent compound, it can be inferred that hexahydrocannabihexol exerts a very intense psychoactive effect on the body. Some believe that it is estimated to be 10-15 times more potent than tetrahydrocannabinol and that it is slightly superior to tetrahydrocannabihexol in its effects. However, there is currently a lack of research to confirm this information.
Like other cannabinoids with psychoactive properties, such as THCB, THCJD, THCPO and HHC, it may affect perception, induce feelings of euphoria or relaxation and could alleviate symptoms of pain and inflammation.
HHCH is recommended for experienced users only, as it is a semi-synthetic cannabinoid that is generally agreed to be much more potent than natural cannabinoids. It should definitely not be driven or operated with any machinery after use.
Side effects and other pitfalls
In the case of (semi)synthetic cannabinoids, they can be much more potent than natural ones. This, of course, multiplies the potential risk of intoxication and overdose, which can end in so-called "bad trip". Adverse psychological effects such as anxiety, paranoia, panic and hallucinations are possible.
Possible other side effects:
- Fatigue and drowsiness
- Dry mouth
- Redness of the eyes
- Increased heart rate
- Headaches
- Nausea (vomiting)
It cannot be excluded that other as yet undetected side effects may occur.
With regard to (semi-)synthetic compounds, experts agree that it is often impossible to prove the purity and safety of products. This also raises the issue of the complex legislation of cannabinoids, across the world. It is not easy to assess what the safety of products is, and at the moment the vast majority of countries, including the Czech Republic, do not have clear regulations to regulate these compounds.
Safety first or laboratory analysis
When you decide to buy any cannabis product, always ask for a laboratory analysis, focus on the composition of the product and choose reputable companies that have been operating in the cannabis market for a few years and are transparent.
If you request third-party lab reports, you'll find objective data on product purity, regulatory compliance (maximum THC limit), safety and more. Verify that the product is free of inappropriate additives, fillers and toxins.
In conclusion: HHCH products and legal status
HHCH is a semi-synthetic cannabinoid derivative that is produced principally in the laboratory by hydrogenation of THCH distillate and its transformation to HHCH.
Currently, you can buy HHCH vape pens, cartridges and liquids (liquids for vaporization), distillate, oils, extracts and concentrates, flower and hash on the cannabis market. The products consist of two stereoisomers, 9(R)-HHCH and 9(S)-HHCH, with the ratio of these isomers affecting the potency and strength of the product.
Under the US Farm Bill, which excluded cannabis with up to 0.3% THC from the list of controlled substances, HHCH is currently legal. However, it can be expected to be in a legal grey area due to its psychoactive effect and may face restrictions or prohibition in some states.
Remember that (semi)synthetic compounds can be much more intense than natural cannabinoids, increasing the potential risk of intoxication and overdose. HHCH products are only suitable for experienced users, who should always evaluate all potential risks before purchasing. There is currently no scientific research to evaluate the safety of this substance.
Author: Hothouse Cucumber
Photo: Shutterstock
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